The James Madison Dukes will take on the MTSU Blue Raiders at 6 p.m. ET on Saturday at Showker Field at Bridgeforth Stadium. James Madison is making a full-time transition to the FBS level this season, as it will be playing in the Sun Belt. The Dukes are favored by 4.5 points in the latest James Madison vs. MTSU odds from Caesars Sportsbook, while the over/under is set at 59. 

Before you make any MTSU vs. James Madison picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 1 of the 2022 college football season on a 45-32 run on all top-rated college football side picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, it has simulated James Madison vs. MTSU 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You absolutely need to see it before locking in your own picks.

So who wins James Madison vs. MTSU? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!