Iowa vs. Vanderbilt odds, line: 2025 college football picks for ReliaQuest Bowl matchup from proven model

The 23rd-ranked Iowa Hawkeyes will take on the 14th-ranked Vanderbilt Commodores in the ReliaQuest Bowl on Wednesday afternoon. Iowa closed out the regular season with a 40-16 win at Nebraska on Nov. 28, while Vanderbilt rolled to a 45-24 win over Tennessee on Nov. 29. The Hawkeyes (8-4), who finished sixth in the Big Ten, are 0-4 against ranked opponents this season. The Commodores (10-2), who tied for fifth in the Southeastern Conference, are 4-2 against ranked foes in 2025. Despite potential opt-outs, the Hawkeyes should have their full roster available. Vanderbilt tight end Eli Stowers, the Mackey Award winner, has opted out and will skip the game.

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Kickoff from Raymond James Stadium in Tampa, Fla., is at noon ET. This will be the first meeting between the schools. The Commodores are 4.5-point favorites in the latest Iowa vs. Vanderbilt odds, while the over/under for total points scored is 46.5 via SportsLine consensus. Before making any Iowa vs. Vanderbilt picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times, and it is 31-19 on rated college football money-line picks since the beginning of the 2024 season. 

The model has simulated Iowa vs. Vanderbilt 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits nearly 60% of simulations!

So who wins Iowa vs. Vanderbilt, and which side of the spread hits nearly 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times! 

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