Iowa State vs. West Virginia odds, line, spread: Proven model reveals college basketball picks, predictions for Feb 23, 2022

Two Big 12 programs that have been struggling since mid-January face off on Wednesday when West Virginia visits Iowa State. Th Cyclones have won their last two games, but lost six of their last ten, while the Mountaineers have won just once in their last 12 outings. However, that single victory came against Iowa State on February 8 in Morgantown when West Virginia won, 79-63.

Game time from the James H. Hilton Coliseum is set for 7 p.m. ET, and the Cyclones are favored by five points in the latest Iowa State vs. West Virginia odds from Caesars Sportsbook, and the over-under is set at 132.5. Before you make any West Virginia vs. Iowa State picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $2,000 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Iowa State vs. West Virginia 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in well over 50 percent of simulations. You absolutely need to see it before locking in your own picks.

Who wins Iowa State vs. West Virginia? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks ... If you're already a member, see the picks below!