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Iowa State vs. Miami odds, line, predictions: Proven college basketball model reveals spread pick for Friday's NCAA Tournament Sweet 16 showdown

The SportsLine Projection Model has generated a strong spread pick for Miami vs. Iowa State in the Midwest Region semifinal
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A berth in the Elite Eight is on the line Friday night when the No. 11-seeded Iowa State Cyclones face the No. 10-seeded Miami Hurricanes in a Midwest Region semifinal. Tipoff is set for 9:59 p.m. ET from the United Center in Chicago.

The Hurricanes are three-point favorites and the over-under for total point scored is 131.5 in the latest Caesars Sportsbook odds for Iowa State vs. Miami in the 2022 NCAA Tournament. (See up-to-date odds for every game this week on our college basketball odds page.)

Before making any Iowa State vs. Miami picks or any other 2022 NCAA Tournament predictions, be sure to check out what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of more than $1,300 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.  

Now, the model has set its sights on the NCAA Tournament and Iowa State vs. Miami on Friday We can tell you it is leaning Over the total, and it also says one side of the spread hits in well over 50 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Iowa State vs. Miami? And which side of the spread covers in well over 50 percent of simulations? ... Join SportsLine right now to find out which side of the spread you should be all over Friday, all from the model on a roll on college basketball picks!

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SportsLine Staff