Iowa State vs. Kansas State odds, line: 2025 college football picks for Dublin, Ireland, Week 0 predictions from proven model

The No. 21 Iowa State Cyclones kick off their 2025 season against the Big 12 Conference rival Kansas State Wildcats in a Week 0 matchup in Ireland on Saturday, Aug. 23. The Wildcats (5-4, 9-4), who were 2-1 against ranked opponents a year ago, had a plus-97 point differential. The Cyclones (11-3, 7-2), who were 9-2 against unranked foes, were plus-114 in point differential.

Kickoff is set for noon ET at Aviva Stadium in Dublin, Ireland. Iowa State leads the all-time series 54-50-4, including a 29-21 win last season. The Wildcats are 3.5-point favorites in the latest Iowa State vs. Kansas State odds, while the over-under for total points scored is set at 49.5. Before making any Iowa State vs. Kansas State picks, check out the college football predictions from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and  was a profitable 27-16 combined on money-line and over/under college football picks in 2024. Anyone following at sportsbooks and on betting apps could have seen STRONG returns!

The model has simulated Iowa State vs. Kansas State 10,000 times and the results are in. We can tell you that the model is leaning Over, and it also says one side of the spread hits in well over 50% of simulations!

So who wins Iowa State vs. Kansas State, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks!