Indiana vs. Purdue odds, prediction: 2026 Big Ten Conference men's college basketball picks from proven model

The Indiana Hoosiers face the seventh-ranked Purdue Boilermakers in a key Big Ten Conference matchup on Friday night. Indiana is coming off a 71-51 loss at Illinois on Sunday, while Purdue dropped a 91-80 decision to the Michigan Wolverines on Tuesday. The Hoosiers (17-9, 8-7 Big Ten), who are 10th in the conference, are 3-6 on the road this season. The Boilermakers (21-5, 11-4 Big Ten), who are tied for third in the league, are 11-3 on their home court.

Tip-off from Mackey Arena in West Lafayette, Ind., is set for 8 p.m. ET. Purdue leads the all-time series 128-94, but Indiana earned a 72-67 win on Jan. 27. Purdue is a 10.5-point favorite in the latest Indiana vs. Purdue odds from DraftKings Sportsbook, while the over/under for total points scored is 148.5. 

Before making any Indiana vs. Purdue picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 16 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 13-7 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Indiana vs. Purdue 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits over 50% of the time!

So who wins Indiana vs. Purdue, and which side of the spread hits over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!