Indiana vs. Oregon prediction, odds, time: 2026 Peach Bowl picks, CFP semifinal bets from proven model

The second matchup of the 2026 College Football Playoff semifinals takes place on Friday as Indiana faces Oregon in the Chick-fil-A Peach Bowl 2026. The No. 1 Hoosiers (14-0) are coming off a dominant 38-3 win over Alabama in the Rose Bowl and remain college football's lone undefeated squad. The No. 5 Ducks (13-1) enter in off a 23-0 shutout victory over Texas Tech as Oregon has already tied a single-season program record for wins.

Kickoff is at 7:30 p.m. ET from the Mercedes-Benz Stadium in Atlanta. Indiana defeated Oregon, 30-20, on Oct. 11, as the programs have split four all-time matchups. The Hoosiers are 3.5-point favorites in the latest Oregon vs. Indiana odds, while the over/under is 47.5.

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month at SportsLine for $1 JOIN NOW. 

Before making any Indiana vs. Oregon picks, be sure to check out the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS game 10,000 times, and it is 31-19 on its top-rated college football money-line picks since the beginning of the 2024 season. 

The model has simulated Oregon vs. Indiana 10,000 times and the results are in. We can tell you that the model is going Under, and it also says one side of the spread hits well over 50% of the time!

So who wins Indiana vs. Oregon, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the Oregon vs. Indiana spread you need to jump on, all from the computer model that has simulated this game 10,000 times!

LIMITED TIME: Use promo code CHAMPIONSHIP to get your first month at SportsLine for $1 JOIN NOW.