Illinois vs. Purdue odds, line, spread: Proven model reveals college football picks, predictions for Week 11, 2022

A Big Ten battle is on tap between the No. 21 Illinois Fighting Illini and the Purdue Boilermakers at noon ET on Saturday at Memorial Stadium. Illinois had its six-game winning streak snapped in an upset loss to Michigan State last week. The Fighting Illini are favored by 6.5 points in the latest Illinois vs. Purdue odds from Caesars Sportsbook, while the over/under is set at 44.5. 

Before you make any Purdue vs. Illinois picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, it has simulated Illinois vs. Purdue 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in 60% of simulations! You absolutely need to see it before locking in your own picks.

So who wins Illinois vs. Purdue? And which side of the spread hits 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.