The Memphis Grizzlies will take on the Charlotte Hornets at 8 p.m. ET Wednesday at FedExForum. The Grizzlies are 6-4 overall and 4-1 at home, while Charlotte is 5-7 overall and 3-5 on the road. Memphis is ranked second in the Southwest Division; the Hornets are ranked third in the Southeast Division. 

Memphis is favored by 4.5 points in the latest Grizzlies vs. Hornets odds from Caesars Sportsbook, and the over-under is set at 229. Before you make any Hornets vs. Grizzlies picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned over $9,000 in profit on its top-rated NBA picks over the past three-plus seasons. The model enters Week 4 of the 2021-22 NBA season up over $500 on all top-rated NBA picks this season. It's also on a stunning 110-73 roll on top-rated NBA picks against the spread that dates back to last season. Anyone following it has seen huge returns.

Now, it has simulated Grizzlies vs. Hornets 10,000 times and the results are in. We can tell you that the model is leaning Under, and it's also generated a point-spread pick that is hitting in well over 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Grizzlies vs. Hornets? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NBA picks... If you're already a member, see the picks below!