Florida vs. South Florida lines, odds: Advanced computer model locks in picks for Saturday's matchup

The 13th-ranked Florida Gators (1-0) look to win their fifth consecutive road opener when they visit the South Florida Bulls (0-1) on Saturday. Kickoff from Raymond James Stadium in Tampa is set for 1 p.m. ET. The Gators are 28.5-point favorites in the latest Florida vs. South Florida odds from Caesars Sportsbook, while the Over-Under for total points scored is 58.5. (See the latest college football lines for all of this week's games on our college football odds page.)

Before you make any South Florida vs. Florida picks and college football predictions, see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 2 of the 2021 season on a 63-45 run on all top-rated college football picks. Anyone who has followed it has seen HUGE returns.

Florida began its 2021 campaign last Saturday with a 35-14 triumph over Florida Atlantic in which it set the school record for most rushing yards in a season opener with 400. Backup quarterback Anthony Richardson led the ground attack with 160 yards on seven carries while Malik Davis also broke the century mark with 104. Davis also found the end zone and fellow running back Dameon Pierce scored twice.

South Florida hopes for a better performance after suffering a 45-0 loss at North Carolina State in its season opener on Sept. 2. The Bulls allowed 525 total yards against the Wolfpack while gaining only 271, including 104 on the ground. South Florida also committed three turnovers - all interceptions as neither Cade Fortin nor Timmy McClain could get the passing game in gear.

Now the model has simulated Florida vs. South Florida 10,000 times, and the results are in. We can tell you that the model is projecting Under on total points, and it has generated a point-spread pick that is hitting in 60 percent of simulations. You ABSOLUTELY need to see it before locking in your own picks.

Who wins the matchup between Florida and South Florida? And which side of the spread is hitting in 60 percent of simulations? ... Join SportsLine right now to see which side of the South Florida vs. Florida spread you need to jump on Saturday, all from the computer model that has crushed its college football picks!