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The No. 10-ranked Alabama Crimson Tide get a shot at revenge from last season's shocking opening loss to Florida State, when they host the Seminoles on Saturday in a big non-conference matchup. FSU won 31-17 in Tallahassee to open the 2025 season. The Seminoles just lost 27-24 to highly regarded SMU, while the Tide rallied from a halftime deficit to roll 45-17 at Kentucky. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Kickoff is set for 3:30 p.m. ET at Bryant-Denny Stadium in Tuscaloosa, Ala. The Crimson Tide are 19.5-point favorites in the latest Florida State vs. Alabama odds. The over/under for total points is 48.5.
Before making any Florida State vs. Alabama picks, check out the college football predictions from the SportsLine Projection Model.
The model simulates every FBS game 10,000 times. It is on a 33-21 run on top-rated college football money-line picks since the 2024 season, and it has been upgraded for the 2026 season to better factor in the transfer portal!
The model has simulated Florida State vs. Alabama 10,000 times and the results are in. The model is going Over on the total, and it also says one side of the spread hits in nearly 70% of simulations!
So who wins Florida State vs. Alabama, and which side of the spread hits nearly 70% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is on a 33-21 run on top-rated CFB picks!
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