Manchester United comes in brimming with confidence as it visits St. Mary's Stadium on Sunday for a 2021-22 English Premier League match with Southampton. Man U crushed Leeds 5-1 in its opener, while the Saints suffered a 3-1 setback to Everton.      

Kickoff is set for 9 a.m ET. Caesars Sportsbook lists Man U as the -180 favorite (risk $180 to win $100) in its latest Southampton vs. Manchester United odds, with Southampton the +470 underdog and a draw priced at +325. The over-under for total goals scored is set at 2.5. (For the latest soccer news and analysis, click here)

Proven soccer expert Martin Green has identified his best bets for the Southampton vs. Manchester United matchup below, and bettors who have followed his advice have cashed in huge. Green is a handicapper who has  covered the game worldwide, and his European soccer picks have generated more than $36,000 for $100 bettors since the 2017-18 season. 

The Red Devils were on fire in the opener, getting a hat trick from Bruno Fernandes and four assists from Paul Pogba. They are intensely motivated to go after a league title after finishing 12 points behind Manchester City last season. Man U has a fearsome attack, and it slaughtered Southampton 9-0 in February.   

The Saints lost half their games to finish 15th last season and lost several key pieces. They will count on newcomer Adam Armstrong, who had 44 goals over the past two seasons at Blackburn, to make a difference. He scored Southampton's only goal in his debut, and the Saints will be eager to avenge the embarrassing loss.                    

Green has taken an in-depth look at the Southampton vs. Manchester United matchup, and he has two confident best bets, including a STRONG play on one side, and a full breakdown of this Premier League battle! You ABSOLUTELY need to see his picks and analysis before making any selections of your own.

What are the best bets you can make on the Southampton vs. Manchester United match on Sunday? ... Join SportsLine now to see Martin Green's best bets on the Southampton vs. Manchester United matchup, all from the soccer insider who's generated more than $36,000 for $100 bettors since the 2017-18 season!