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Trevor Lawrence and the red-hot Jacksonville Jaguars head across the pond to London, England, to face Jalen Hurts and the Philadelphia Eagles, who aim to end a two-game losing streak. The Jaguars rolled the Patriots 35-6 before escaping Cincinnati 22-17 to improve to 3-1. The Eagles have dropped a pair after starting 2-0, blown out by the Bears in Week 3 and blowing a double-digit lead at home to the Rams. Jacksonville is 7-6 all-time in England; this is the second-ever game in the country for the Eagles, who may be without star RB Saquon Barkley (hamstring). Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Kickoff is set for 9:30 a.m. ET from Tottenham Hotspur Stadium in London. The latest Eagles vs. Jaguars odds have Jacksonville as 6.5-point favorites. The over/under for total points scored is 42.5.
Before making any Eagles vs. Jaguars picks or 2026 NFL Week 5 predictions, you NEED to see which side the proven SportsLine projection model is on.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 5 of the 2026 NFL season on a 55-44 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!
Now, the model has locked in another confident pick for Eagles vs. Jaguars in the NFL Week 5 2026 matchup.
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