The No. 7 Duke Blue Devils will take on the South Carolina Upstate Spartans at 6:30 p.m. ET on Friday at Cameron Indoor Stadium. The Blue Devils got off to a good start under first-year head coach Jon Scheyer, beating Jacksonville in a 71-44 final. The Blue Devils are favored by 28 points in the latest Duke vs. South Carolina Upstate odds from Caesars Sportsbook, while the over/under is set at 149.5. 

Before you make any South Carolina Upstate vs. Duke picks and predictions, you'll want to see what the SportsLine Projection Model is saying.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past six years, the proprietary computer model has generated an impressive profit of more than $1,200 for $100 players on its top-rated college basketball picks against the spread. Anybody who has followed it has seen profitable returns.

Now, it has simulated Duke vs. South Carolina Upstate 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in almost 60% of simulations. You absolutely need to see it before locking in your own picks.

So who wins Duke vs. South Carolina Upstate? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college basketball picks... If you're already a member, see the picks below!