The Duke Blue Devils will take on the Northwestern Wildcats at 4 p.m. ET next Saturday at Wallace Wade Stadium. The Wildcats are favored by 2.5-points in the latest Duke vs. Northwestern odds from Caesars Sportsbook and the over-under is set at 49.5. Before you make any Northwestern vs. Duke picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 3 of the 2021 season on a 67-50 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has simulated Duke vs. Northwestern 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread has all the value. You absolutely need to see it before locking in your own picks.

So who wins Duke vs. Northwestern? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!