Duke vs. Michigan odds, prediction: 2026 college basketball picks from proven model

One of the top college basketball matchups of the season unfolds on Saturday when No. 3 Duke takes on top-ranked Michigan in the 2026 Edward Jones Capital Showcase at Capital One Arena in Washington D.C. Michigan is 25-1 on the season, while Duke is 24-2. 

Tipoff is set for 6:30 p.m. ET. The Wolverines are 2.5-point favorites in the latest Michigan vs. Duke odds, while the over/under is 150.5. 

Before making any Duke vs. Michigan picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 16 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 13-7 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated this matchup 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits well over 60% of the time!

So who wins Duke vs. Michigan, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!