Duke vs. Florida odds, prediction: 2025 ACC/SEC Challenge picks from proven model

No. 4 Duke will host the defending champion and No. 15 Florida Gators in one of the marquee matchups in the ACC/SEC Challenge 2025. Duke (8-0) is coming off a Thursday win over Arkansas, 80-71, as the Blue Devils are 4-0 at home. Florida (5-2) defeated Providence, 80-72, on Friday, one day after losing to TCU. This will be Florida's first true road game of the season.

Tipoff is 7:30 p.m. ET at Cameron Indoor Stadium in Durham, N.C. Duke is 5-2 all-time versus Florida. The Blue Devils are 8.5-point favorites in the latest Duke vs. Florida odds, while the over/under is 156.5.

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Before making any Florida vs. Duke picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and has returned over $2,000 in betting profit for $100 players on its top-rated college basketball picks over the past three-plus seasons. Anyone following could have seen HUGE returns!

The model has simulated Duke vs. Florida 10,000 times and the results are in. We can tell you that the model is leaning Under, and it also says one side of the spread hits well over 60% of the time!

So who wins Florida vs. Duke, and which side of the spread hits well over 60% of the time? Join SportsLine right now to see which side of the Duke vs. Florida spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!

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