The No. 2 seed Duke Blue Devils take on the No. 15 seed Cal State Fullerton Titans in a 2022 NCAA Tournament first round matchup at 7:10 p.m. ET on Friday. Duke is favored by 18.5 points at Caesars Sportsbook, while the Over-Under is set at 145 (see up-to-date odds for every game this week on our college basketball odds page). 

Before making any Duke vs. Cal State Fullerton picks, you NEED to check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of almost $1,500 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns.

The model knows Duke is loaded with a plethora of playmakers, including Paolo Banchero. The freshman forward is averaging 17.0 points and 7.8 rebounds per game. Banchero leads a Duke offense that is averaging 80.2 points per game, which ranks ninth in the country. The Blue Devils are also in the top 10 nationally in field-goal percentage (48.49), and they've won 14 of their last 17 games. 

The model has also taken into account that Cal State Fullerton enters Friday's matchup full of confidence after winning seven of its last nine games. The Titans are led by E.J. Anosike, who's averaging 16.5 points and 8.3 rebounds per game. Anosike has recorded nine double-double this season, including in two of his last three outings. 

Now, the model has set its sights on Duke vs. Cal State Fullerton. We can tell you the model is leaning Over the total, and it also says one side of the spread hits in well over 60 percent of simulations! You ABSOLUTELY need to see it before locking in any college basketball picks.

Who wins Duke vs. Cal State Fullerton? And which side of the spread hits in well over 60 percent of simulations? ... Join SportsLine right now to find out which side of the Cal State Fullerton vs. Duke spread you should be all over, all from the model on a roll on college basketball picks!