Diamondbacks vs. Phillies odds, line, prediction: 2026 MLB picks for Saturday afternoon from proven model

The Arizona Diamondbacks look to make it back-to-back wins in the series when they take on the Philadelphia Phillies in a key National League matchup on Saturday. Arizona defeated Philadelphia 5-4 on Friday night in the first game of the series. The Diamondbacks (8-6), second in the NL West, are 3-4 on the road this season. The Phillies (6-7), who are fourth in the NL East, are 3-4 on their home field in 2026.

First pitch from Citizens Bank Park in Philadelphia is set for 1:05 p.m. ET. The Diamondbacks lead the all-time series 96-92, including wins in six of the last nine meetings. Philadelphia is a -135 favorite on the money line (risk $135 to win $100) in the latest Diamondbacks vs. Phillies odds, while the over/under, is 8.5. Before making any Diamondbacks vs. Phillies picks, or MLB predictions, you NEED to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It was a profitable 35-29 on top-rated MLB money-line picks last season. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following could have seen strong returns!

The model has simulated Diamondbacks vs. Phillies 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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