Creighton vs. St. John's odds, prediction: 2026 Big East Conference men's college basketball picks from proven model

The 17th-ranked St. John's Red Storm look to extend their winning streak to 13 games when they battle the Creighton Bluejays in a key Big East Conference matchup on Saturday. Creighton is coming off a 91-84 win over fifth-ranked UConn on Wednesday, while St. John's topped Marquette 76-70 that same night. The Bluejays (14-13, 8-8 Big East), who are tied for fourth in the conference, are 3-7 on the road this season. The Red Storm (21-5, 14-1 Big East), who lead the league by one-half game over UConn, are 12-2 on their home court.

Tip-off from Madison Square Garden in New York is set for noon ET. Creighton leads the all-time series 19-14, but St. John's has won three straight, including 90-73 on Jan. 10. St. John's is a 12.5-point favorite in the latest Creighton vs. St. John's odds from DraftKings Sportsbook, while the over/under for total points scored is 153.5. 

Before making any Creighton vs. St. John's picks, check out the college basketball predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every college basketball game 10,000 times and entered Week 16 on a sizzling 11-1 run on top-ranked over/under picks dating back to last year, and is on an 13-7 run on top-rated CBB side picks. Anyone following could have seen HUGE returns!

The model has simulated Creighton vs. St. John's 10,000 times and the results are in. The model is leaning Over, and it also says one side of the spread hits nearly 70% of the time!

So who wins Creighton vs. St. John's, and which side of the spread hits nearly 70% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has simulated this matchup 10,000 times!