Cowboys vs. Eagles odds, line: 2025 NFL picks, Week 1 predictions from proven computer model
SportsLine's model has locked in its best bets for the Thursday, Sept. 4, game between the Dallas Cowboys and Philadelphia Eagles
The defending Super Bowl champion Philadelphia Eagles will kick off the 2025 NFL regular season when they take on the Dallas Cowboys on Thursday, Sept. 4. Philadelphia swept the season series in 2024, earning 41-7 and 34-6 wins. The Cowboys (7-10), who finished third in the NFC East last season, were 5-3 on the road a year ago. The Eagles (14-3), who won the NFC East en route to the Super Bowl title, were 8-1 on their home field.
Kickoff from Lincoln Financial Field in Philadelphia is set for 8:20 p.m. ET. The Eagles have defeated the Cowboys in each of the last three games played in Philadelphia. The Eagles are 7-point favorites in the latest Cowboys vs. Eagles odds, while the over-under for total points scored is set at 46.5.
Before making any Cowboys vs. Eagles picks, check out the NFL predictions from the SportsLine Projection Model.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered the 2025 Super Bowl on a 31-15 betting hot streak on top-rated NFL picks – a stunning 67% success rate. Longer term, it is on a 211-143 roll on top-rated NFL picks that dates back to the 2017 season and a 65-36 roll on top-rated NFL picks since Week 7 of 2022.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone following has seen HUGE returns!
The model has simulated Cowboys vs. Eagles 10,000 times and the results are in. We can tell you the model is leaning Over on the total. It also says one side of the spread hits well over 50% of the time!
Who wins Cowboys vs. Eagles, and which side of the spread hits well over 50% of the time? Join SportsLine right now to find out which side of the spread you should be all over, all from the model that is up well over $7,000 on its NFL picks!
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