An AFC matchup on Thursday Night Football features the Indianapolis Colts (1-2-1) visiting the Denver Broncos (2-2). Kickoff is set for 8:15 p.m. ET from Empower Field. Denver is a three-point favorite in the latest Colts vs. Broncos odds from Caesars Sportsbook, and the over/under for total points scored is 42. Before making any Colts vs. Broncos picks of your own, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 5 of the 2022 NFL season on an incredible 140-105 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

The model knows Denver quarterback Russell Wilson is a confident leader who owns a big arm. The nine-time Pro Bowler can move the pocket with athleticism and superb awareness. Wilson is completing 61% of his throws for 980 yards with four passing touchdowns and one interception.

The model also knows Indianapolis quarterback Matt Ryan is a savvy veteran. Ryan possesses a strong arm and solid mechanics. The four-time Pro Bowler has been up and down through four games, but is fourth in the league in passing yards (1,125) with five passing touchdowns and five interceptions. He's also tossed 300-plus yards in two games this season.

Now, the model has set its sights on Colts vs. Broncos on Thursday Night Football. We can tell you the model is leaning Under the total, and it also says one side of the spread cashes in well over 50% of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

So who wins Colts vs. Broncos on Thursday Night Football? And which side of the spread cashes well over 50% of the time? Join SportsLine now to see which side of the Colts vs. Broncos spread to back, all from the model that's an amazing 140-105 on NFL picks!