The Denver Broncos will welcome the Indianapolis Colts to Empower Field at Mile High on Thursday Night Football. Kickoff in Denver is set for 8:15 p.m. ET. The Broncos are favored by three points in the latest Colts vs. Broncos odds from Caesars Sportsbook, while the over/under is 42. Before you make any Colts vs. Broncos picks or any other NFL predictions, you NEED to see which side R.J. White is on. 

White, a Fantasy and gambling editor for CBS Sports, consistently crushes as SportsLine's No. 1 NFL expert in picks against the spread, and went 445-378-24 on his ATS picks from 2017-21, which returned $2,542 to $100 players. He's also gone an amazing 36-24-2 on his NFL picks involving the Colts, meaning he's well-qualified for this selection. 

He's well-known for cashing out big in the Westgate Las Vegas SuperContest twice since 2015. White also cashed big on his NFL futures in 2021, including nailing Jonathan Taylor as the NFL rushing leader at 10-1. Anyone who has followed him is WAY UP!

The expert knows Indianapolis is excelling on defense. Opponents are averaging just 21.3 points per game against the Colts, who are in the top six in total defense, rushing defense, and yards per carry allowed. The Colts are also in the top 10 in passing defense, giving up only 207.5 yards per game.

The expert also knows that Denver has allowed only 19 points in two home games, and the Broncos are in the top five in scoring defense. The Broncos have the best red zone efficiency on defense of any team in the league this season, with opponents generating only 284.8 total yards per game.

Now, White has locked in another confident against the spread pick for Colts vs. Broncos. We can tell you he's leaning Under the total, but he knows a crucial X-factor makes one side of the spread a MUST-BACK! You ABSOLUTELY need to see what it is before locking in any picks of your own.

Who wins Colts vs. Broncos on Thursday Night Football? And what critical X-factor makes one side of the spread a must-back? ... Join SportsLine right now to see which side of the Colts vs. Broncos spread to jump on, all from the expert who's an outstanding 36-24 on Colts picks!