College football odds, lines, spreads: Picks, predictions for Week 1, 2021 from proven model

After a five-game soft launch last Saturday, the college football schedule ramps up with a full slate of action Week 1 that wraps around Labor Day Weekend. In the marquee matchups, Clemson is favored by three points against Georgia in the latest Week 1 college football odds from Caesars Sportsbook. In other matchups of ranked teams, Alabama is -18.5 against Miami, Texas is -8 against Louisiana and Wisconsin is -4.5 against Penn State.

Before making any college football picks for Week 1, be sure to see what the SportsLine Projection Model has to say. 

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,600 for $100 players on its top-rated college football picks against the spread. It also enters Week 1 of the 2021 season on a 57-37 run on all top-rated college football picks. Anyone who has followed it has seen HUGE returns.

Now, it has studied the latest college football odds from Caesars (see the latest college football lines for each matchup this week on our college football odds page), simulated every single play for Week 1 of FBS college football, and the results are in. 

One of the college picks the model is high on in Week 1: LSU (-2.5) goes to Pasadena and easily covers against UCLA. Quarterback Max Johnson throws for almost 400 yards in the simulations as the Tigers cover more than 60 percent of the time. 

Another prediction: Iowa (-4) covers against Indiana in a Big Ten matchup. The Hawkeyes cover in more than 50 percent of simulations, while the under (46) hits well over 60 percent of the time. 

The model has also made the call on who wins and covers in every other FBS matchup, and it is calling for a top national title contender to go down HARD. You ABSOLUTELY need to see its college football picks before locking in any of your own. 

So which college football teams should you back this week? And which title contender goes down? ... Join SportsLine now to see who wins and covers every single game, all from the model that has returned over $3,600 in profit on top-rated ATS picks over the past five-plus seasons!