The fifth-ranked Clemson Tigers (3-0) look to continue their dominance over No. 21 Wake Forest (3-0) when they meet in a key Atlantic Coast Conference Atlantic Division matchup on Saturday. The Demon Deacons won the division with a 7-1 mark and finished 2021 with a 11-3 overall record. Clemson was second in the division at 6-2 and was 10-3 overall. The Tigers lead the all-time series 69-17-1, including a 26-10-1 record at Wake Forest.

Kickoff from Truist Field in Winston-Salem, N.C., is set for noon ET. The Tigers are 7.5-point favorites in the latest Clemson vs. Wake Forest odds from Caesars Sportsbook, while the over/under for total points scored is 56.5. (See up-to-date odds for every game this week on our college football odds page.) 

Before you make any Clemson vs. Wake Forest picks and college football predictions, you NEED to see the predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,300 for $100 players on its top-rated college football picks against the spread. It enters Week 4 of the 2022 college football season on a 51-43 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen HUGE returns!

The model knows the Tigers are averaging more than 41 points per game and are led by junior quarterback DJ Uiagalelei, who has completed 57 of 88 passes (64.8 percent) for 662 yards and five touchdowns. He has been picked off once, but has a rating of 144.4. Uiagalelei can be a dangerous runner as well. He is second on the team in rushing with 117 yards on 27 carries (4.3 average) and one touchdown. With a win this week, Uiagalelei can become only the 17th Clemson player since World War II to earn 15 career victories as the Tigers' starting quarterback.

The model also knows the Demon Deacons have a potent offense, led by junior quarterback Sam Hartman. Hartman has completed 44 of 71 passes (62 percent) for 625 yards and seven touchdowns with two interceptions. Last season, he was a finalist for the Manning Award and the Johnny Unitas Golden Arm Award. Hartman threw for 4,228 yards in 2021, ranking sixth in ACC history and first in Wake Forest history. He also rushed for 11 touchdowns, the second-most in program history by a Wake Forest quarterback.

Now, the model has set its sights on Clemson vs. Wake Forest. We can tell you it is leaning Over the total, and it also says one side of the spread hits in well over 50% of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Clemson vs. Wake Forest? And which side of the spread hits well over 50% of the time? ... Join SportsLine right now to find out which side of the Clemson vs. Wake Forest spread you should be all over Saturday, all from the model on a roll on college football picks!