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The Clemson Tigers enter Week 3 at 1-1 after a brutal 51-10 loss at No. 11 LSU to open the season, though they rebounded with a 22-7 win over Georgia Southern last week behind freshman quarterback Tait Reynolds, who replaced Christopher Vizzina as the starter. The North Carolina Tar Heels have been one of the early surprises of 2026, going 2-0 under first-year head coach Bill Belichick with quarterback Billy Edwards Jr. completing the transfer from Wisconsin, including a Week 0 win over TCU and a 35-3 blowout of East Tennessee State, and they arrive at Death Valley on Saturday looking to hand Clemson a second loss. Claim the latest Polymarket promo code SPORTSLINE to get a $50 trading bonus after a $10 deposit:
Kickoff is set for noon ET at Memorial Stadium in Clemson, South Carolina. The Tigers are 3.5-point favorites in the latest North Carolina vs. Clemson odds, while the over/under is 44.5 points.
Before making any Clemson vs. North Carolina picks, check out the college football predictions from the SportsLine Projection Model.
The model simulates every FBS game 10,000 times. It is on a 33-21 run on top-rated college football money-line picks since the 2024 season, and it has been upgraded for the 2026 season to better factor in the transfer portal!
The model has simulated North Carolina vs. Clemson 10,000 times and the results are in. The model is going Over on the total, and it also says one side of the spread hits in well over 50% of simulations!
So who wins North Carolina vs. Clemson, and which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that is on a 33-21 run on top-rated CFB picks!
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