Cavaliers vs. Pacers odds, line: Proven model reveals picks for NBA matchup on January 6

The Indiana Pacers will look to snap a 12-game losing streak when they battle the Cleveland Cavaliers in a Central Division matchup on Tuesday. Cleveland is coming off a 114-110 loss to the Detroit Pistons on Saturday, while Indiana dropped a 135-127 decision at Orlando that same day. The Cavaliers (20-17), who have won three of four, are 7-8 on the road this season. The Pacers (6-30), who are 4-18 within the Eastern Conference, are 5-14 on their home floor. Donovan Mitchell (rest) will miss the game for Cleveland, while Isaiah Jackson (concussion) is out for Indiana.

Tip-off from Gainbridge Fieldhouse in Indianapolis is set for 7 p.m. ET. The Pacers lead the all-time series 111-106, but the Cavaliers have won both meetings this season by double digits. Cleveland is a 6.5-point favorite in the latest Cavaliers vs. Pacers odds from SportsLine consensus, while the over/under for total points scored is 236.5.

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SportsLine's model simulates every NBA game 10,000 times and has returned well over $10,000 in betting profit for $100 players on its top-rated NBA picks over the past eight-plus seasons. The model enters Week 12 of the 2025-26 NBA season on a sizzling 33-15 roll on top-rated NBA spread picks dating back to last season. Anyone following could have seen HUGE returns!

The model has simulated Cavaliers vs. Pacers 10,000 times and the results are in. We can tell you that the model is going Under on the point total, and it also says one side of the spread hits in well over 50% of simulations.

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