Cardinals vs. White Sox odds, lines: Proven model reveals MLB picks for May 26, 2021, Wednesday afternoon interleague matchup

The Chicago White Sox go for the interleague series sweep when they meet the St. Louis Cardinals on Wednesday afternoon. First pitch is at 2:10 p.m. ET at Guaranteed Rate Field in Chicago. William Hill Sportsbook lists Chicago as the -203 favorite (risk $203 to win $100) in the latest Cardinals vs. White Sox odds. The Over-Under for total runs is set at 8.5 (see the latest lines for every game on our MLB odds page) in this matchup.

Before making any Cardinals vs. White Sox picks, you NEED to see the latest MLB predictions from the SportsLine Projection Model.

This model, which simulates every pitch of every game 10,000 times, had a banner 2019 season, the league's last full schedule, returning more than $1,400 on its top-rated money-line and run-line picks. It is off to a fast start in 2021, going 61-44 on top-rated MLB money-line picks through eight weeks, returning well over $700. Anyone following it has seen HUGE rewards!

Now, it has set its sights on Cardinals vs. White Sox. We can tell you it's leaning Under, and it also says one side of the money line has all the value! You ABSOLUTELY need to see it before locking in any MLB picks of your own.

So who wins Cardinals vs. White Sox? And which side of the money line has all the value? ... Join SportsLine right now to find out which side of the Cardinals vs. White Sox money line you should be all over on Wednesday, all from the model that was up over $1,400 on MLB picks in 2019!