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Buffalo vs. Central Michigan prediction, odds, line: Advanced college football model reveals picks for Wednesday night's MAC crossover matchup

SportsLine's projection model has generated Week 11 CFB picks for the MACtion contest between the Buffalo Bulls and Central Michigan Chippewas
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The Buffalo Bulls will look to bounce back from their first MAC loss of the season when they battle the Central Michigan Chippewas in Wednesday night MACtion. The Bulls (5-4, 4-1), who are tied with Ohio and Bowling Green for the MAC East lead, were beaten by Ohio 45-24 last week. The Chippewas (3-6, 2-3), who are tied for third in the MAC West with Eastern Michigan and Western Michigan, are coming off a 35-22 win at Northern Illinois last week. Buffalo has won the last two meetings in the series – 43-20 in 2019 and 34-24 in 2018.

Kickoff from Kelly/Shorts Stadium in Mount Pleasant, Mich., is set for 7 p.m. ET. The Chippewas are listed as 2.5-point favorites in the latest Buffalo vs. Central Michigan odds from Caesars Sportsbook, while the over/under for total points scored is 53. (See up-to-date odds for every game this week on our college football odds page.) 

Before you make any Buffalo vs. Central Michigan picks or college football predictions, you NEED to see the predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen HUGE returns!

The model knows Buffalo junior quarterback Cole Snyder, a transfer from Rutgers, helps power the offense. He has completed 188 of his 319 passes (58.9%) for 2,145 yards and 14 touchdowns with six interceptions. He has also rushed for four scores. Snyder has thrown for six touchdowns and three interceptions over the past three games, completing 20 of 31 attempts (64.5%) for 277 yards, three touchdowns and two interceptions in a 34-7 win at Massachusetts on Oct. 15.

The model also knows Central Michigan is led by sophomore running back Lew Nichols III. Nichols has carried 160 times for 561 yards (3.5 average) and six touchdowns. He also has 20 receptions for 128 yards (6.4 average). Nichols has had a solid career at CMU, earning the Mid-American Conference Freshman of the Year Award in 2021 and the MAC Offensive Player of the Year Award in 2022.

Now, the model has set its sights on Buffalo vs. Central Michigan. We can tell you it is leaning Over the total, and it also says one side of the spread hits well over 50% of the time! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins Buffalo vs. Central Michigan? And which side of the spread hits well over 50% of the time? ... Join SportsLine right now to find out which side of the Buffalo vs. Central Michigan spread you should be all over Wednesday, all from the model on a roll on college football picks!

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SportsLine Staff

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