The Cleveland Browns will face the Jacksonville Jaguars in the first preseason game for both teams. Kickoff from TIAA Bank Field in Jacksonville, Fla., is set for 7 p.m. ET. Jacksonville leads the all-time regular-season series 12-6, but this will be the first preseason meeting between the teams, who once were in the same division. The Browns beat the Jaguars 27-25 at Jacksonville in a game last season. Jacksonville is a 3.5-point favorite in the latest odds from Caesars Sportsbook, while the Over-Under for total points scored is 37.

Before locking in any Browns vs. Jaguars picks or NFL predictions, you NEED to see what SportsLine's all-time No. 1 NFL expert, Mike Tierney, has to say. 

A national sportswriter whose work appears in The New York Times and Los Angeles Times, Tierney has covered the NFL for decades and reported from seven Super Bowls. Tierney does not consider himself a pet lover. But he likes 'dogs, preferring to evaluate each game from the underdog's point of view. 

Tierney has used that philosophy to crush the NFL, going 187-147 against the spread the past three seasons. All-time at SportsLine (2016-20), Tierney is 347-291 on all NFL picks, returning $2,534 to $100 players.    

Tierney has had plenty of success in games involving the Jacksonville Jaguars. He went 23-12 in his last 35 against-the-spread picks in Jacksonville games, returning $1,013 to $100 players. Anybody who has been following him is WAY UP!

Now, he's studied Browns vs. Jaguars from every possible angle. We can tell you he's found a critical X-factor that makes one side of the spread a MUST BACK! You ABSOLUTELY need to see it before you lock in your own NFL picks.

So who wins Browns vs. Jaguars? And what critical X-factor makes one side of the spread a MUST-BACK? ... Join SportsLine right now to see which side of the Browns vs. Jaguars spread you should be all over, all from the expert who's 23-12 on picks involving Jacksonville!