Brewers vs. Red Sox odds, line, prediction: 2026 MLB picks for Wednesday afternoon from proven model

The Milwaukee Brewers face the Boston Red Sox in the third and deciding game of their interleague series on Wednesday afternoon. Boston is coming off a 3-2 win on Tuesday night. The Brewers (8-3), who lead the National League Central Division, have won three of their five road games this season. The Red Sox (3-8), who are fifth in the American League East, are 2-3 on their home field in 2026.

First pitch from Fenway Park in Boston is set for 1:35 p.m. ET. The Red Sox lead the all-time series 224-199, but the Brewers have won six of the past eight meetings. Boston is a -139 favorite on the money line (risk $139 to win $100) in the latest Brewers vs. Red Sox odds, while the over/under, is 7.5. Before making any Brewers vs. Red Sox picks, or MLB predictions, you NEED to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every MLB game 10,000 times. It was a profitable 35-29 on top-rated MLB money-line picks last season. It also excelled at making home run prop picks in 2025, returning nearly 30 units of profit. Anybody following could have seen strong returns!

The model has simulated Brewers vs. Red Sox 10,000 times and the results are in. The model is going Over on the total, and is also says one side of the money line has ALL the value!

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