The Jacksonville Jaguars will aim for their second straight victory abroad when they take on the Buffalo Bills at Tottenham Hotspur Stadium in London on Sunday. After losing back-to-back home contests, Jacksonville (2-2) posted a 23-7 triumph over Atlanta at London's Wembley Stadium last weekend. The Bills (3-1), who could have edge rusher Von Miller (knee) on the field for the first time this season, rolled past Miami 48-20 at home in Week 4 to extend their winning streak to three games.

Kickoff is set for 9:30 a.m. ET. Buffalo is a 5.5-point favorite in the latest Bills vs. Jaguars odds, while the over/under for total points scored is 48.5. Before making any Jaguars vs. Bills picks of your own, you NEED to check out the NFL predictions from the SportsLine Projection Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 5 of the 2023 NFL season on an incredible 168-118 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 22-10 roll on top-rated NFL picks since Week 7 of last season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP.

The model knows Buffalo has responded to its season-opening overtime loss to the New York Jets with a vengeance, outscoring its opponents 123-33 during its three-game winning streak. The Bills are looking to join the 1942 Chicago Bears as the only teams in NFL history to win four consecutive games by at least 28 points. Quarterback Josh Allen leads the league with a 74.8 completion percentage after going 21-of-25 for 320 yards and four touchdowns against the Dolphins last week.

The model also is aware that Jacksonville split its previous 10 games in London, with one of the wins being a 34-31 triumph over Buffalo at Wembley Stadium in 2015. Including the playoffs, the Jaguars have won three of their last five meetings with the Bills, most recently registering a 9-6 victory in 2021 as 15.5-point underdogs. Linebacker Josh Allen has gotten off to a strong start this season and shares the NFL lead with six sacks after posting his second three-sack performance of 2023 last week against the Falcons.

Now, it has set its sights on Bills vs. Jaguars. We can tell you the model is leaning Under the total, and it also says one side of the spread cashes in over 60% of simulations! You ABSOLUTELY need to see it before locking in any NFL picks.

Who wins Bills vs. Jaguars in London? And which side of the spread hits in over 60% of simulations? ... Join SportsLine right now to find out which side of the Jaguars vs. Bills spread you should be all over Sunday, all from the model on a 168-118 roll on NFL picks!