The Arkansas State Red Wolves will take on the Memphis Tigers at 7 p.m. ET on Saturday at Centennial Bank Stadium. Arkansas State won its season opener, 40-21 over Central Arkansas, after finishing 4-7 last season. Memphis won its season opener over Nicholls State, 42-17. The Tigers were 8-3 last season and beat FAU in the Montgomery Bowl, 25-10. 

The Tigers are favored by 5.5 points in the latest Arkansas State vs. Memphis odds from Caesars Sportsbook, and the over-under is set at 64.5. Before you make any Memphis vs. Arkansas State picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 2 of the 2021 season on a 63-45 run on all top-rated college football picks. Anyone who has followed it has seen HUGE returns.

Now, it has simulated Arkansas State vs. Memphis 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Arkansas State vs. Memphis? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks... If you're already a member, see the picks below!