The Alabama Crimson Tide will take on the Southern Miss Golden Eagles at 7:30 p.m. ET on Saturday at Bryant-Denny Stadium. The Crimson Tide are 3-0 overall and 1-0 at home, while Southern Miss is 1-2 overall and 0-1 on the road. The Crimson Tide are favored by 45-points in the latest Alabama vs. Southern Miss odds from Caesars Sportsbook, and the over-under is set at 58.5. Before you make any Southern Miss vs. Alabama picks, you'll want to see the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. It also enters Week 4 of the 2021 season on a 72-58 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, it has simulated Alabama vs. Southern Miss 10,000 times and the results are in. We can tell you that the model is leaning Over, and it's also generated a point-spread pick that is hitting in nearly 60 percent of simulations. You absolutely need to see it before locking in your own picks.

So who wins Alabama vs. Southern Miss? And which side of the spread is a must-back? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its college football picks.