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    49ers vs. Cardinals prediction, odds, line, spread: Proven model reveals NFL picks, best bets for Week 18, 2023

    The SportsLine projection model simulated Arizona vs. San Francisco and released its picks, predictions, and best bets for this NFL Week 18 game
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    An NFC West battle is on tap between the San Francisco 49ers and the Arizona Cardinals at 4:25 p.m. ET on Sunday at Levi's Stadium. San Francisco is 12-4 overall and 7-1 at home, while Arizona is 4-12 overall and 3-4 on the road. The 49ers are ranked first in the NFC West; Arizona is ranked fourth. The 49ers are 10-6 and the Cardinals are 8-8 against the spread this season.

    San Francisco is favored by 14 points in the latest 49ers vs. Cardinals odds from Caesars Sportsbook, and the over/under is set at 39.5. Before locking in any Cardinals vs. 49ers picks or NFL predictions, you'll want to see what the SportsLine Projection Model is saying.

    The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 18 of the 2022 NFL season on an incredible 160-113 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 14-6 roll on top-rated NFL picks since Week 7 of this season. The model ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that span. Anyone who has followed it is WAY UP!

    Now, it has simulated 49ers vs. Cardinals 10,000 times and the results are in. We can tell you that the model is leaning Over on the point total, and it's also generated a point-spread pick that is hitting in well over 50% of simulations. You absolutely need to see it before locking in your own picks.

    So who wins 49ers vs. Cardinals? And which side of the spread hits well over 50% of the time? Join SportsLine right now to see which side of the spread you need to jump on, all from the computer model that has crushed its NFL picks.

    GET VEGAS EXPERT PICKS FOR NFL, MLB, NBA, CBB, GOLF, NHL, HORSE RACING AND MORE - PLUS ADVANCED COMPUTER SIMULATIONS, WINNING TOOLS, AND MORE!

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    SportsLine Staff

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