2026 Wild Card Weekend NFL odds, score predictions: SportsLine AI reveals picks for every game

The 2026 NFL Wild Card Weekend schedule features two games on Saturday, three on Sunday and one 'Monday Night Football' matchup between the Houston Texans and Pittsburgh Steelers. Monday's intriguing matchup will pit quarterback C.J. Stroud and the Houston Texans against 21-year veteran Aaron Rodgers and the Pittsburgh Steelers. The Texans are favored by 3.5 points in what's one of the largest Wild Card Weekend NFL lines.

Sunday's other largest spreads include Rams (-10.5) vs. Panthers, 49ers vs. Eagles (-3.5) and Chargers vs. Patriots (-3.5). The smallest spreads in Wild Card Weekend include Packers vs. Bears (-1) and Bills (-1.5) vs. Jaguars. The top seeds, Seattle in the NFC, and Denver, in the AFC, have the week off.

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Before making any 2026 Wild Card Weekend NFL picks, be sure to check out the NFL score predictions from the SportsLine's self-learning AI.

Built using cutting-edge artificial intelligence and machine learning techniques by SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each game. The AI predictions are determined by statistically learning from each team's historical data then quantitatively evaluating the strength of the opponents defense by assigning a numeric value out of 100 called a matchup score. 

Once a prediction is formulated, the AI rating is generated using the prediction, the matchup score, and the odds of the market. For example, you could see a 5-star rating on an Over bet if a team is facing a poor defense, their prediction differs from the line and there are favorable odds.

In addition, SportsLine AI is the first fully automated predictive model at SportsLine. It continuously refreshes on the most recent available data and can help you spot the biggest discrepancies in the lines. SportsLine's AI has nailed more than 2,000 4.5- and 5-star prop picks since the start of the 2023 season! Anyone who has followed it is WAY UP!

After analyzing every game in Wild Card Weekend, the AI says the Steelers (+3.5), who won the AFC North title, cover against the visiting Texans. Quarterback Aaron Rodgers has played well this season. In 16 games, he has completed 65.7% of his passes for 3,322 yards and 24 touchdowns with seven interceptions for a rating of 94.8.

SportsLine AI rates the Steelers as a B+ money line pick and also predicts a 22-21 Houston win on average.

SportsLine AI has generated against the spread, over/under and money-line picks for every game in Wild Card Weekend! In fact, the AI has generated a dozen HIGHLY-COVETED A+ picks! You ABSOLUTELY NEED to see the AI analysis before making any Wild Card Weekend NFL bets.

Which NFL bets do you need to make NOW for Wild Card Weekend? And which must-see NFL picks are worthy of an A+ rating? ... Join SportsLine now to see the top 2026 Wild Card Weekend NFL picks, all from the self-learning SportsLine AI that has nailed a COLOSSAL 2,000+ top-rated picks since the start of last season!

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