2022 U.S. Open men's odds, picks: Kyrgios vs. Khachanov quarterfinals best bets and predictions from expert who called 60-1 longshot

Sparks could fly Tuesday night when Nick Kyrgios and Karen Khachanov face off in the men's quartefinals at the 2022 U.S. Open at the Billie Jean King National Tennis Center. It's a rematch of an epic five-set Kyrgios victory in the third round of the 2020 Australian Open, and the mercurial Kyrgios has been known to put on a show. Both are in the U.S. Open quarterfinals for the first time, but Kyrgios is now the +160 favorite to win the tournament after a series of upsets.  

First serve is scheduled for 9 p.m. on Arthur Ashe Court in New York City. Kyrgios is the $525 favorite (risk $525 to win $100) in the latest Kyrgios vs. Khachanov U.S. Open men's tennis odds from Caesars Sportsbook. Khachanov is a +350 underdog, and the Over/Under for total games played is 38.5. Before you make any men's tennis picks on the 2022 U.S. Open, you need to see who Sean Calvert is backing.

Calvert is the famed handicapper who called Stan Wawrinka winning the 2014 Australian Open at 60-1 -- the last Australian title won by someone other than Djokovic, Rafael Nadal or Roger Federer. Calvert took down a huge score on Dominic Thiem winning the 2019 Indian Wells title at 80-1, among many stunning calls. 

In addition, Calvert nailed Casper Ruud making the 2022 French Open final, winning big for anyone who backed him. Sean also hit all three of his picks at plus-money odds in the Wimbledon final, including Novak Djokovic winning three sets to one at +275.

The expert knows these players have split their two previous meetings, with Khachanov taking a relatively easy three-set affair at Cincinnati in 2019 before the battle in Melbourne in January 2020. Both are known for huge serves, and Kyrgios had 99 winners and 33 aces in that Australian Open match while Khachanov had 75 and 21. Kyrgios won the first set 6-2, but the other four went to tiebreaks. 

Kyrgios made the Wimbledon final in July and is seeking his first semifinal at Flushing Meadows after defeating reigning champ and world No. 1 Daniil Medvedev in the third round Sunday. Khachanov need five sets to beat Pablo Carreno Busta in his Sunday match but will be motivated to reach his first Grand Slam semifinal. 

Now, Calvert has pored over the latest Khachanov vs. Kyrgios U.S. Open odds and released his coveted best bets. He has two CONFIDENT picks, including a strong handicap play, and his full brreakdown of the match. You ABSOLUTELY need to see all of Calvert's picks and analysis of the Khachanov vs. Kyrgios 2022 U.S. Open quarterfinal before you bet.

Who wins the Kyrgios vs. Khachanov men's quarterfinal at the 2022 U.S. Open on Tuesday? Which best bet is a MUST-BACK if you want to cash in big? ... Join SportsLine right now to see Sean Calvert's 2022 U.S. Open picks for Khachanov vs. Kyrgios, all from the renowned tennis expert who called Stan Wawrinka winning the Australian Open at 60-1!