The 2022 NCAA Tournament Final Four takes place on Saturday, with No. 1 Kansas vs. No. 2 Villanova in the day's first matchup at 6:09 p.m. ET. The Jayhawks are 4.5-point favorites in a rematch of the 2018 Final Four and the over-under is 133 in the latest 2022 Final Four odds from Caesars Sportsbook. The nightcap features the first-ever March Madness matchup between No. 2 Duke and No. 8 North Carolina at 8:49 p.m. ET. The Blue Devils are 4.5-point favorites with the over-under at 151 in the 2022 NCAA Tournament odds.

Before you make any college basketball bets or Final Four 2022 parlays, you need to see what the SportsLine projection model has to say.

The SportsLine Projection Model simulates every Division I college basketball game 10,000 times. Over the past five-plus years, the proprietary computer model has generated an impressive profit of over $1,200 for $100 players on its top-rated college basketball picks against the spread. Anyone who has followed it has seen HUGE returns! 

Now, the model has crunched the numbers for Saturday's Final Four, with against-the-spread and over-under picks for both games. A successful parlay of these picks would pay out 12-1!

We can tell you it is leaning Over 133 total points in Kansas vs. Villanova. The model also locked in spread and total picks for both games, and for one game it says one side of the spread cashes in 60 percent of the time! You ABSOLUTELY need to see what it's picking before you make any plays of your own.

So which Final Four teams cover? And which picks should you make for an epic 12-1 payout? ... Join SportsLine right now to see the 2022 Final Four parlay picks, all from the model that's generated a profit of over $1,200 for $100 players on its top-rated college basketball picks!