UTSA (12-1) and No. 24 San Diego State (11-2) will face off in the 2021 Tropical Smoothie Frisco Bowl at 7:30 p.m. ET on Tuesday night. This game will take place at Toyota Stadium in Frisco, Texas. 

The Aztecs are favored by 2.5 points in the latest UTSA vs. San Diego State odds from Caesars Sportsbook, while the Over-Under for total points is set at 49. (See the latest college football lines for all of this week's games on our college football odds page.) Kickoff is set for 7:30 p.m. ET.

Before you consider your UTSA vs. San Diego State picks or college football predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,700 for $100 players on its top-rated college football picks against the spread. It also enters the 2021-22 college football bowl season on a 43-29 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

The model knows UTSA had one of the top rushing attacks in Conference USA this past season. They were ranked second with 188.6 rushing yards per game and 25 rushing touchdowns. The Roadrunners also average 4.6 yards per carry and will look to establish that in this bowl game. Sincere McCormick put up big numbers for UTSA this year, but he has opted out for this bowl game. Look for the Roadrunners to lean more on mobile quarterback Frank Harris and backup running backs Brenden Brady and B.J. Daniels. Both backs averaged 4.7 yards per carry this season. 

The model also knows San Diego State produced one of the best defenses in the Mountain West Conference this past year. The Aztecs rank second in total defense and allow 319.6 total yards per game. Teams have struggled to establish a ground game against this unit. San Diego State only allows 77.6 rushing yards per contest. Junior defensive lineman Cameron Thomas has been terrific for this group. He has logged 68 total tackles, 20 tackles for loss, and 11.5 sacks. 

Now, it has set its sights on UTSA vs. San Diego State. We can tell you the model is leaning under the total and it also says one side of the spread hits in 60 percent of simulations! You ABSOLUTELY need to see it before locking in any college football picks.

Who wins UTSA vs. San Diego State? And which side of the spread hits in 60 percent of simulations? ... Join SportsLine right now to find out which side of UTSA vs. San Diego State spread you should be all over Tuesday, all from the model on a roll on college football picks!