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2021 Duke's Mayo Bowl odds, picks: North Carolina vs. South Carolina selections from advanced computer model for Thursday's bowl game

The SportsLine Projection Model, which is up almost $3,600 over the past five-plus years, has simulated the 2021 Duke's Mayo Bowl matchup between the Tar Heels and Gamecocks 10,000 times
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The North Carolina Tar Heels (6-6) look to improve their record in the all-time series when they take on the South Carolina Gamecocks (6-6) in the 2021 Duke's Mayo Bowl on Thursday. North Carolina posted a 24-20 victory in 2019 to improve to 35-19-4 against South Carolina. Kickoff from Bank of America Stadium in Charlotte, N.C. is scheduled for 11:30 a.m. ET.

The Tar Heels are 11-point favorites in the latest North Carolina vs. South Carolina odds from Caesars Sportsbook, while the over-under for total points scored is 57.5. (See the latest college football lines for all of this week's games on our college football odds page.)

Before making any South Carolina vs. North Carolina picks or college football predictions, you need to see what the SportsLine Projection Model has to say.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It also entered the third week of the 2021-22 college football bowl season on a 43-30 run on all top-rated college football side picks. Anyone who has followed it has seen HUGE returns.

The model knows North Carolina alternated losses and wins over its final nine regular-season games after posting back-to-back victories in mid-September. Junior quarterback Sam Howell has accounted for 34 touchdowns this year, throwing for 23 scores while ranking second on the team with 11 rushing TDs -- including eight during his current five-game streak. Sophomore wideout Josh Downs, who has hauled in eight touchdown passes, has set school records this season with 98 receptions and 1,273 yards.

The model also knows South Carolina has been inconsistent in 2021, rotating wins and losses over its final eight contests after suffering two straight defeats in late September. With Luke Doty sidelined following foot surgery and Jason Brown entering the transfer portal, quarterback Zeb Noland will make his fifth start of the season on Thursday. The graduate student has completed 50-of-89 pass attempts in six outings this year for 608 yards with six touchdowns and just one interception.

Now the model has simulated North Carolina vs. South Carolina 10,000 times, and the results are in. We can tell you that the model is leaning Over on the total, and it also says one side of the spread hits well over 50 percent of the time. You ABSOLUTELY need to see it before locking in your own picks.

Who wins the North Carolina vs. South Carolina matchup in Thursday's Duke's Mayo BowlAnd which side of the spread hits well over 50 percent of the time? ... Join SportsLine right now to see which side of the South Carolina vs. North Carolina spread you need to jump on Thursday, all from the computer model on a 43-30 run on its top-rated college football side picks!

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SportsLine Staff