A number of 2021 Copa Libertadores favorites open play during the first leg of the Round of 16 on Tuesday. Among the pre-tournament favorites to open play are Boca Juniors of Argentina, Atletico Mineiro of Brazil, Sao Paulo of Brazil and Argentina's Racing Club.

Sao Paulo has been installed as a -125 favorite in the Sao Paulo vs. Racing Club odds from William Hill Sportsbook, while Racing Club is a +450 underdog and a draw is listed at +210. Atletico Mineiro is a +175 favorite in the Boca Juniors vs. Atletico Mineiro match, while Boca Juniors is a +200 underdog. In the third match, Fluminense of Brazil is a +170 favorite in the Cerro Porteno vs. Fluminense odds. Cerro Porteno is a +200 underdog, while a draw is +180.

Before you make any 2021 Copa Libertadores predictions, you MUST see what soccer expert Roger Gonzalez has to say.

Gonzalez grew up playing competitive soccer before becoming one of the world's foremost soccer journalists. After covering soccer all over the globe -- a Champions League final in Italy, Copa America, and professional leagues in Argentina -- Gonzalez returned to the U.S. as CBS Sports' top soccer expert. 

Now, Gonzalez has broken down the Round of 16 at the 2021 Copa Libertadores. We can tell you Gonzalez is taking the under 2.5 in the Boca Juniors vs. Atletico Mineiro matchup. "With this being the first leg of the round of 16 and both teams looking to give themself life ahead of the second leg, I expect a low scoring match and for the under to hit," Gonzalez says.

Gonzalez has two other plays, including one with a plus-money payout on the match's outcome. You ABSOLUTELY need to see his picks and analysis before you bet!

So who should you back in Tuesday's Round of 16 matchups at Copa Libertadores? And which prop bets should you be all over? ... Join SportsLine now to get Roger Gonzalez's STRONG picks for Tuesday's games, all from the soccer insider who has his finger on the pulse of South American soccer!