No team 46 years has opened 3-0 against the spread and entered Game 4 as a double-digit underdog. What's more, this line is a full two TDs. Arizona is coming off a solid whipping of Dallas. Josh Dobbs is settling in at QB. WR Marquise Brown, listed as questionable, looks like a go. Not that the Cards need any more motivation, but looking at this massive number could provide a jolt.

San Francisco's excellent defense has allowed just one completion over 30 yards this season (31) and teams have a completion percentage of zero on throws at least 20 yards downfield vs. that unit (obviously, there could be a catch-and-long run) via Sharp Football Analysis. Dobbs' longest completion has gone Under this number in two of three games.

What makes the Cardinals a tough out for this San Francisco team is their defensive pressure, combined with a mobile QB on the opposite side. Those two things can help neutralize a team as potent as the 49ers. Neutralize them enough to keep this one closer than expected.