Through two weeks, the 2021 NFL season has not disappointed. Week 1 was full of upsets and games decided in the final minutes. In Week 2, Patrick Mahomes's Chiefs and Lamar Jackson's Ravens delivered an instant classic on Sunday Night Football; the Seattle Seahawks and Tennessee Titans went to overtime; and two more games, the Cardinals vs. Vikings and Cowboys vs. Chargers, were decided by field goals in the final seconds.
With the Green Bay Packers blowout win over the Detroit Lions on Monday Night Football, against the spread underdogs notched a slight 9-7 advantage over the favorites in Week 2, which was a big shift from Week 1 when the underdogs posted a 12-4 record. Will Week 3 be the week where the betting favorites prevail? Or will it be all about the ATS underdogs again?
The NFL Week 3 schedule features another full slate of games with several intriguing matchups including Chiefs vs. Chargers, where Justin Herbert will face off with Patrick Mahomes; the Buccaneers vs. Rams, in a matchup between arguably the top two teams in the NFC; and Cowboys vs. Eagles on Monday Night Football, where fans will get another taste of one of the nastiest rivalries in the NFL.
Here is a full rundown of the NFL Week 3 slate of games and TV schedule, as well as odds, picks, and predictions for several matchups.
Which Fantasy Football sleepers, breakouts and busts should you target and fade? And which QB shocks the NFL with a top-five performance? Join SportsLine now to get 2021 Fantasy Football cheat sheets for every single position, all from the model that called Josh Allen's huge season.
Carolina Panthers vs. Houston Texans
- Panthers vs. Texans date and time: Thursday, September 23 at 8:20 p.m. ET
- Panthers vs. Texans spread: Panthers -7.5
- Panthers vs. Texans over-under: 43.5
- Panthers vs. Texans moneyline: Panthers -380, Texans +300
- Panthers vs. Texans TV Coverage: NFL Network
Expert Panthers vs. Texans picks HERE.
Washington Football Team vs. Buffalo Bills
- Bills vs. Washington date and time: Sunday, September 26 at 1 p.m. ET
- Bills vs. Washington spread: Bills -9
- Bills vs. Washington over-under: 45.5
- Bills vs. Washington moneyline: Bills -420, Washington +320
- Bills vs. Washington TV coverage: Fox
Chicago Bears vs. Cleveland Browns
- Bears vs. Browns date and time: Sunday, September 26 at 1 p.m. ET
- Bears vs. Browns spread: Browns -7
- Bears vs. Browns over-under: 46.5
- Bears vs. Browns moneyline: Browns -330, Texans +260
- Bears vs. Browns TV coverage: Fox
Expert Bears vs. Browns picks HERE.
Baltimore Ravens vs. Detroit Lions
- Ravens vs. Lions date and time: Sunday, September 26 at 1 p.m. ET
- Ravens vs. Lions spread: Ravens -8.5
- Ravens vs. Lions over-under: 49.5
- Ravens vs. Lions moneyline: Ravens -420, Lions +320
- Ravens vs. Lions TV coverage: CBS
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Indianapolis Colts vs. Tennessee Titans
- Colts vs. Titans date and time: Sunday, September 26 at 1 p.m. ET
- Colts vs. Titans spread: Titans -5
- Colts vs. Titans over-under: 48
- Colts vs. Titans moneyline: Titans -260, Colts +210
- Colts vs. Titans TV coverage: CBS
Los Angeles Chargers vs. Kansas City Chiefs
- Chiefs vs. Chargers date and time: Sunday, September 26 at 1 p.m. ET
- Chiefs vs. Chargers spread: Chiefs -6.5
- Chiefs vs. Chargers over-under: 55.5
- Chiefs vs. Chargers moneyline: Chiefs -250, Chargers +205
- Chiefs vs. Chargers TV coverage: CBS
New Orleans Saints vs. New England Patriots
- Saints vs. Patriots date and time: Sunday, September 26 at 1 p.m. ET
- Saints vs. Patriots spread: Patriots -3
- Saints vs. Patriots over-under: 41.5
- Saints vs. Patriots moneyline: Patriots -160, Saints +140
- Saints vs. Patriots TV coverage: Fox
Atlanta Falcons vs. New York Giants
- Giants vs. Falcons date and time: Sunday, September 26 at 1 p.m. ET
- Giants vs. Falcons spread: Giants -3
- Giants vs. Falcons over-under: 48
- Giants vs. Falcons moneyline: Falcons +140, Giants -160
- Giants vs. Falcons TV coverage: Fox
Which Fantasy Football sleepers, breakouts and busts should you target and fade? And which QB shocks the NFL with a top-five performance? Join SportsLine now to get 2021 Fantasy Football cheat sheets for every single position, all from the model that called Josh Allen's huge season.
Cincinnati Bengals vs. Pittsburgh Steelers
- Steelers vs. Bengals date and time: Sunday, September 26 at 1 p.m. ET
- Steelers vs. Bengals spread: Steelers -4
- Steelers vs. Bengals over-under: 44
- Steelers vs. Bengals moneyline: Steelers -200, Bengals +170
- Steelers vs. Bengals TV coverage: CBS
Arizona Cardinals vs. Jacksonville Jaguars
- Cardinals vs. Jaguars date and time: Sunday, September 26 at 1 p.m. ET
- Cardinals vs. Jaguars spread: Cardinals -7.5
- Cardinals vs. Jaguars over-under: 52
- Cardinals vs. Jaguars moneyline: Cardinals -360, Jaguars +285
- Cardinals vs. Jaguars TV coverage: Fox
Expert Cardinals vs. Jaguars picks HERE.
New York Jets vs. Denver Broncos
- Broncos vs. Jets date and time: Sunday, September 26 at 2:05 p.m. ET
- Broncos vs. Jets spread: Jets -10.5
- Broncos vs. Jets over-under: 41
- Broncos vs. Jets moneyline: Broncos -650, Jets +450
- Broncos vs. Jets TV coverage: CBS
Miami Dolphins vs. Las Vegas Raiders
- Raiders vs. Dolphins date and time: Sunday, September 26 at 2:05 p.m. ET
- Raiders vs. Dolphins spread: Raiders -3.5
- Raiders vs. Dolphins over-under: 45
- Raiders vs. Dolphins moneyline: Dolphins +155, Raiders -180
- Raiders vs. Dolphins TV coverage: CBS
Who wins every NFL game? And which teams will sink your bankroll? Join SportsLine now to get NFL picks every week, all from the model that simulates every game 10,000 times and is up almost $8,000.
Tampa Bay Buccaneers vs. Los Angeles Rams
- Buccaneers vs. Rams date and time: Sunday, September 26 at 4:25 p.m. ET
- Buccaneers vs. Rams spread: Buccaneers -1
- Buccaneers vs. Rams over-under: 55.5
- Buccaneers vs. Rams moneyline: Rams +100, Buccaneers -120
- Buccaneers vs. Rams TV coverage: Fox
Seattle Seahawks vs. Minnesota Vikings
- Vikings vs. Seahawks date and time: Sunday, September 26 at 4:25 p.m. ET
- Vikings vs. Seahawks spread: Seahawks -2
- Vikings vs. Seahawks over-under: 55
- Vikings vs. Seahawks moneyline: Vikings -125, Seahawks +105
- Vikings vs. Seahawks TV coverage: Fox
Green Bay Packers vs. San Francisco 49ers
- Packers vs. 49ers date and time: Sunday, September 26 at 8:20 p.m. ET
- Packers vs. 49ers spread: 49ers -3.5
- Packers vs. 49ers over-under: 49.5
- Packers vs. 49ers moneyline: Packers +160, 49ers -190
- Packers vs. 49ers TV coverage: NBC
Philadelphia Eagles vs. Dallas Cowboys
- Cowboys vs. Eagles date and time: Monday, September 20 at 8:15 p.m. ET
- Cowboys vs. Eagles spread: Cowboys -4
- Cowboys vs. Eagles over-under: 52
- Cowboys vs. Eagles moneyline: Cowboys -210, Eagles +175
- Cowboys vs. Eagles TV coverage: ESPN
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Which Fantasy Football sleepers, breakouts and busts should you target and fade? And which QB shocks the NFL with a top-five performance? Join SportsLine now to get 2021 Fantasy Football cheat sheets for every single position, all from the model that called Josh Allen's huge season.
