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The San Francisco 49ers look to move to 8-1 on the season and 5-1 in the conference when they battle the Dallas Cowboys in a key NFC matchup on Sunday afternoon. The 49ers enter as 4.5-point favorites despite being bitten hard by the injury bug. Running back Christian McCaffrey (hamstring) and Demarcus Robinson (ankle) are both on the mend and are expected to play. In another key game involving NFC West teams, the Rams take on the Cardinals (+7.5) as Los Angeles looks to stay in the hunt for the division crown. Visit our Kalshi promo code review and get a $55 bonus after $25+ in trades with the Kalshi promo code SPORTSLINE55:
There are a number of other intriguing matchups in Week 10, including several divisional matchups. Among them include Bills vs. Jets (+7), Panthers vs. Saints (-1.5), Jaguars vs. Titans (+10), Vikings vs. Packers (-3.5) and Steelers vs. Bengals (-3.5) on 'Sunday Night Football.' The Chargers are seeking to end an 11-game losing streak dating back to last season when they battle the Ravens (-5.5) on 'Monday Night Football.'
Before locking in any NFL parlays for this slate, make sure you see what SportsLine's advanced computer model has to say.
The model, which simulates every NFL game 10,000 times, is up more than $5,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 10 of the 2026 NFL season on a 62-52 run on top-rated picks dating back to 2024. Anybody following could have seen HUGE returns!
The model has scoured the Week 10 NFL odds and locked in five confident NFL best bets. If you successfully parlay its picks, you'd be looking at a massive payout of over 20-1!
One pick from the model: The model backs the Over 40.5 in the Dolphins vs. Colts matchup, as it hits in 77% of simulations.
The model is also backing a favorite to win over 70% of the time! You ABSOLUTELY NEED to see its NFL picks for every game before you make any NFL bets of your own!
So which NFL teams should you back in Week 10, and which five picks should you lock in RIGHT NOW? ... Join SportsLine now to see the top parlay picks for this week, all from the model on a 62-52 roll on top-rated NFL picks!
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Written by Daniel Kohn
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