The Cardinals have had some offensive problems over the last two weeks and are riding a six-game losing streak. But I like this battle of Heisman Trophy-winning QBs from Oklahoma to feature smooth-running offenses and lots of points. Arizona is allowing 30 points per game at home this year. Over is the top play here.

This seems like a shaky spot for the fragile Browns, whose stretch of four wins in five games seems less impressive than the numbers indicate. Cleveland totaled between 13-27 points in the four of those contests and has stumbled ATS in its last four on the road. Leaving bone-chilling Cleveland to play in the desert makes the flighty Browns vulnerable.

In a battle between No. 1 overall picks, Baker Mayfield and the Browns head west to take on the Cardinals. The difference will be the Browns’ ability to apply pressure. Look for Cleveland’s defensive line to give Kyler Murray and the Cardinals problems. And we still don't know if Arizona can stop the run, which figures to be the Browns’ plan in this matchup.