Indy -2.5 should be out there at some point, and I'd snatch that up. The Jags have a great defense, but it hasn't played nearly as well as it did last year, and it's had to deal with injuries in the secondary. Andrew Luck should be able to take advantage of that weakness, and the Indy run game rolled to 220+ yards in each of their last two games before the bye. Can Jacksonville shut down both aspects of the Colts offense? If you back Jacksonville, are you really going to take Blake Bortles vs. Andrew Luck on such a short number? I know I'm not.

Leonard Fournette's return is huge, and this is a series the Jaguars have dominated lately (two straight wins, four of last five). Look for Jacksonville's pass defense to make Andrew Luck less efficient than normal. Grab the points.