Isbel went 2-for-3 in Thursday's 9-1 loss to the White Sox.
Smith struck out the side to earn the save Thursday against Boston.
Cantillo (11-9) notched the win Thursday against Boston, striking out two while allowing one hit and two walks in five shutout innings of relief.
Dobnak (3-5) earned the loss after allowing six runs (four earned) on six hits and one walk over 1.1 innings against the White Sox on Thursday. He struck out one.
Perez went 1-for-3 with a solo homer, a walk and a strikeout during Thursday's 9-1 loss to the White Sox.
The Royals recalled Bivens from the Arizona Complex League on Thursday.
Cantillo is slated to pitch in bulk relief behind opener Daniel Espino in Thursday's game at Boston, Zack Meisel of The Athletic reports.
Garcia is absent from the lineup for Thursday's contest versus the White Sox.
Caglianone is not in the lineup for Thursday's game versus the White Sox.
The Royals placed Cruz on the paternity leave list Thursday.
