Valdez was removed from Friday's contest against the Cubs with left hamstring discomfort, Aiden Stepansky of MLB.com reports.
Lowe is not in the lineup for Friday's game against the Cubs.
Dotel is slated to start Friday's game against the Cubs at Wrigley Field, Dominic Campbell of SI.com reports.
The Pirates activated O'Hearn (quadriceps) from the 10-day injured list Friday.
The Pirates optioned Simon to Triple-A Indianapolis on Friday.
Jones (4-6) earned the win over the White Sox on Thursday, allowing one hit and issuing two walks while striking out eight batters over seven scoreless innings.
Montgomery earned a save against the White Sox on Thursday, allowing one hit and striking out one batter over one scoreless inning.
Cruz went 3-for-4 with a home run and an additional RBI in Thursday's 2-0 win over the White Sox.
The Pirates recalled Kelly from Triple-A Indianapolis on Thursday.
Valdez isn't in the lineup for Thursday's game against the White Sox.
| PITCHING | INN | W | K | HA | ER | BBI | |
| P. Skenes | Paul Skenes | 6.2 | 0.47 | 6.6 | 3.9 | 1.6 | 1.3 |
| Relievers | Relievers | 2.8 | 0.1 | 3.3 | 3.2 | 1.8 | 1.7 |
| HITTING | H | R | RBI | TB | BB | SB | |
| J. Mangum | Jake Mangum | 1.21 | 0.47 | 0.34 | 1.56 | 0.21 | 0.27 |
| B. Lowe | Brandon Lowe | 1.09 | 0.66 | 0.73 | 2.23 | 0.39 | 0.02 |
| B. Reynolds | Bryan Reynolds | 1.01 | 0.63 | 0.56 | 1.82 | 0.55 | 0.06 |
| E. Valdez | Esmerlyn Valdez | 1.0 | 0.59 | 0.63 | 1.94 | 0.4 | 0.08 |
| R. O`Hearn | Ryan O`Hearn | 1.11 | 0.56 | 0.71 | 1.89 | 0.37 | 0.02 |
| N. Gonzales | Nick Gonzales | 1.19 | 0.58 | 0.45 | 1.69 | 0.25 | 0.03 |
| E. Rodriguez | Endy Rodriguez | 0.9 | 0.5 | 0.55 | 1.62 | 0.52 | 0.09 |
| J. Gonzalez | Jacob Gonzalez | 0.94 | 0.5 | 0.57 | 1.56 | 0.32 | 0.09 |
| H. Davis | Henry Davis | 0.68 | 0.41 | 0.42 | 1.36 | 0.31 | 0.04 |
KEY PLAYER INJURIESS. Horwitz, O. Cruz, E. Sisk, K. Griffin NOT PROJECTED TO START:Jhostynxon Garcia, Jared Triolo, Billy Cook, Tyler Callihan, Marcell Ozuna, Rafael Flores Batting order and lineup confirmed and provided by Rotowire. | |||||||
| PITCHING |
| Paul Skenes |
| Relievers |
| HITTING |
| Jake Mangum |
| Brandon Lowe |
| Bryan Reynolds |
| Esmerlyn Valdez |
| Ryan O`Hearn |
| Nick Gonzales |
| Endy Rodriguez |
| Jacob Gonzalez |
| Henry Davis |
| INN | W | K | HA | ER | BBI |
| 6.2 | 0.47 | 6.6 | 3.9 | 1.6 | 1.3 |
| 2.8 | 0.1 | 3.3 | 3.2 | 1.8 | 1.7 |
| H | R | RBI | TB | BB | SB |
| 1.21 | 0.47 | 0.34 | 1.56 | 0.21 | 0.27 |
| 1.09 | 0.66 | 0.73 | 2.23 | 0.39 | 0.02 |
| 1.01 | 0.63 | 0.56 | 1.82 | 0.55 | 0.06 |
| 1.0 | 0.59 | 0.63 | 1.94 | 0.4 | 0.08 |
| 1.11 | 0.56 | 0.71 | 1.89 | 0.37 | 0.02 |
| 1.19 | 0.58 | 0.45 | 1.69 | 0.25 | 0.03 |
| 0.9 | 0.5 | 0.55 | 1.62 | 0.52 | 0.09 |
| 0.94 | 0.5 | 0.57 | 1.56 | 0.32 | 0.09 |
| 0.68 | 0.41 | 0.42 | 1.36 | 0.31 | 0.04 |
