The Pirates activated O'Hearn (quadriceps) from the 10-day injured list Friday.
Dotel is slated to start Friday's game against the Cubs at Wrigley Field, Dominic Campbell of SI.com reports.
The Pirates optioned Simon to Triple-A Indianapolis on Friday.
Cruz went 3-for-4 with a home run and an additional RBI in Thursday's 2-0 win over the White Sox.
Jones (4-6) earned the win over the White Sox on Thursday, allowing one hit and issuing two walks while striking out eight batters over seven scoreless innings.
Montgomery earned a save against the White Sox on Thursday, allowing one hit and striking out one batter over one scoreless inning.
The Pirates placed Ashcraft on the 15-day injured list Thursday with right arm discomfort, retroactive to Monday.
Valdez isn't in the lineup for Thursday's game against the White Sox.
The Pirates recalled Kelly from Triple-A Indianapolis on Thursday.
Bender (lower leg) has ceased baseball activities and will get another opinion on the lingering soreness in his shin, MLB.com reports.
