Happ went 1-for-4 with a three-run home run in Tuesday's 5-4 loss to the Diamondbacks.
Webb (6-4) allowed two runs on one hit and one walk without recording a strikeout in one inning, taking the loss and a blown save in Tuesday's 5-4 loss to the Diamondbacks.
Holmes allowed two hits and two walks while striking out five over seven scoreless innings in a no-decision versus the Diamondbacks on Tuesday.
King allowed five hits, two walks and a hit batsman while striking out seven over seven scoreless innings in a no-decision versus the Pirates on Tuesday.
Kelly is absent from the lineup for Tuesday's game against the Diamondbacks.
Wynns and the Cubs agreed on a minor-league contract Tuesday.
Sheets isn't in the lineup for Tuesday's game against the Pirates.
Padres manager Craig Stammen said after Monday's loss to the Pirates that Machado is dealing with a bruise on the inside of his index finger, Annie Heilbrunn of The San Diego Union-Tribune reports.
Kelly went 1-for-3 with a solo home run and a walk in Monday's 7-0 win over Arizona.
Miller was sent outright to Triple-A Iowa on Monday.
